Sucralfate for ulcers: what it does and how to use it
Sucralfate is a medicine that helps ulcers heal by coating the sore area. It forms a sticky barrier over the ulcer so acid and enzymes can’t irritate it. Unlike acid reducers, sucralfate works locally—very little gets into your bloodstream. That makes it a good choice when a protective coat is needed instead of lowering stomach acid.
How to take sucralfate and common dosing tips
Most people take sucralfate on an empty stomach. Typical dosing for a duodenal ulcer is 1 gram four times daily (about one hour before meals and at bedtime) or 2 grams twice daily. Always follow your doctor’s instructions—doses can vary.
Here are key points to remember: take it before eating, swallow tablets whole or dissolve the suspension as directed, and keep a regular schedule so the medicine is working when your stomach is active.
Interactions, side effects, and safety notes
Sucralfate can bind other drugs and reduce their absorption. If you take medicines like phenytoin, digoxin, warfarin, levothyroxine, or some antibiotics (fluoroquinolones, tetracyclines), separate them by about two hours before or after sucralfate. Ask your pharmacist for each specific drug.
Constipation is the most common side effect. You might also notice dry mouth, an upset stomach, or nausea. Because sucralfate contains aluminum, people with severe kidney disease may have trouble clearing it. If you have kidney problems, tell your doctor—another treatment may be safer.
Sucralfate doesn’t lower stomach acid, so it’s not a direct substitute for proton pump inhibitors (PPIs) or H2 blockers. Sometimes doctors use sucralfate together with acid-suppressing drugs, but that depends on the type and cause of the ulcer.
Pregnant or breastfeeding? Talk to your provider. Sucralfate is often used when needed, but always check with your clinician before starting any medicine while pregnant.
How long until you feel better? Many people notice less pain in a few days, but ulcers usually need several weeks to heal. Your doctor will set a treatment length—often 4 to 8 weeks—and may repeat tests or an endoscopy if symptoms persist.
Watch for warning signs: sudden severe abdominal pain, black or bloody stools, vomiting blood, or fainting. Those are red flags—get medical help right away.
If you’re buying the medicine online or switching pharmacies, double-check the form (tablet vs suspension), dosing, and storage instructions. Keep all your prescribers and your pharmacist in the loop so they can spot interactions or duplications in therapy.
Want a quick checklist? Take sucralfate on an empty stomach, separate other meds by two hours, watch for constipation, and contact your doctor for severe symptoms or if you have kidney disease. Simple steps like these make treatment safer and more effective.
