Tag: opioid tolerance

How to Tell Opioid Hyperalgesia Apart from Tolerance: Key Clinical Signs

• by Colin Edward Egan
• on 13 Jan 2026

Learn how to distinguish opioid-induced hyperalgesia from tolerance - key signs like spreading pain, allodynia, and worsening pain with higher doses. This is not addiction. It’s a physiological side effect that’s often misdiagnosed.