Indinavir Dosage: Simple Steps for Safe Use

If you or someone you know has been prescribed indinavir, the first question is usually “how much should I take?” Indinavir is a protease inhibitor used to treat HIV, and getting the dose right is key to keeping the virus under control while minimizing side effects.

Most adults start with a dose of 800 mg taken twice daily, spaced at least four hours apart and with a full glass of water. The drug works best when you keep a consistent schedule, so try to take it at the same times each day. If you have liver problems, a doctor may lower the dose to 400 mg twice daily.

Adjusting the Dose for Specific Situations

Kids and teens don’t get the same amount as adults. For children weighing less than 35 kg (about 77 lbs), doctors typically calculate the dose based on body weight—around 15 mg per kilogram, split into two doses each day. Adolescents over 35 kg usually follow the adult dosing plan, but the final decision always depends on a doctor’s evaluation.

People with kidney issues also need a tweak. If your creatinine clearance is below 30 mL/min, your doctor may reduce the dose to 400 mg twice daily. Never change the amount on your own—talk to your healthcare provider before making adjustments.

Tips to Reduce Side Effects and Boost Effectiveness

Indinavir can cause kidney stones, so staying hydrated is a must. Aim for at least 2 to 3 liters of water a day, especially if you’re taking the medication in hot weather or exercising. Avoid taking antacids that contain aluminum or magnesium within two hours of your indinavir dose, as they can lower absorption.

If you miss a dose, take it as soon as you remember—provided it’s been less than two hours since the scheduled time. If it’s been longer, skip the missed dose and resume your regular schedule. Don’t double up; that can increase the risk of side effects like nausea or a rash.

While on indinavir, keep an eye on your lab results. Your doctor will likely check liver enzymes and kidney function every few months. Any sudden increase in pain during urination, blood in the urine, or swelling should prompt a call to your provider right away.

Finally, combine indinavir with other antiretroviral drugs as part of a complete regimen. Sticking to the full treatment plan is what keeps the virus suppressed and reduces the chance of resistance.

Bottom line: follow the prescribed dose, stay well‑hydrated, and keep regular check‑ups. With these habits, indinavir can be an effective part of HIV therapy without causing unnecessary trouble.